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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of study design, such as the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However, 프라그마틱 무료 too much heterogeneity can lead to problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be a great way to identify the cause-effect relationship between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation trials.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the features of a pragmatic study that include the recruitment process, the design and implementation of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.